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Tirzepatide for the treatment of obesity: Rationale and design of the SURMOUNT clinical development program - Roux - 2023 - Obesity - Wiley Online Library

In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small- molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with

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