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glp-1 receptor agonist dpp-4 inhibitor combination not recommended Why are DPP-4 (Dipeptidyl Peptidase-4) inhibitors not typically combined with GLP-1 (Glucagon-Like Peptide-1) receptor agonists in patients with type 2 diabetes?

Name: glp-1 receptor agonist dpp-4 inhibitor combination not recommended Why are DPP-4 (Dipeptidyl Peptidase-4) inhibitors not typically combined with GLP-1 (Glucagon-Like Peptide-1) receptor agonists in patients with type 2 diabetes?
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GLP-1 Patches vs. GLP-1 Injections: What You Need to Know

In four recent placebo-controlled clinical trials, dysesthesia, an unpleasant sensation that's perceived on or under the skin, was reported as a side effect of the GLP-1 agonist semaglutide in 5-23% of recipients.

Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists - ScienceDirect

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