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I kept seeing patients on semaglutide and tirzepatide and asking myself: what is this much weight loss doing to their skeleton? Turns out the research is more unsettling than most people realize.
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In the SUMMIT trial, researchers examined cardiovascular outcomes of treatment with tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Full trial results and Plain Language Summary: https://nej.md/4hRGaTY Medthreads
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